1inz
From Proteopedia
(New page: 200px<br /> <applet load="1inz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1inz" /> '''SOLUTION STRUCTURE OF THE EPSIN N-TERMINAL ...) |
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'''SOLUTION STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSIN'''<br /> | '''SOLUTION STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1INZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1INZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:02:42 2008'' |
Revision as of 14:02, 15 February 2008
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SOLUTION STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSIN
Overview
Epsin is a protein that binds to the Eps15 homology (EH) domains, and is, involved in clathrin-mediated endocytosis. The epsin N-terminal homology, (ENTH) domain (about 140 amino acid residues) is well conserved in, eukaryotes and is considered to be important for actin cytoskeleton, organization in endocytosis. In this study, we have determined the, solution structure of the ENTH domain (residues 1-144) of human epsin by, multidimensional nuclear magnetic resonance spectroscopy. In the, ENTH-domain structure, seven alpha-helices form a superhelical fold, consisting of two antiparallel two-helix HEAT motifs and one three-helix, ARM motif, with a continuous hydrophobic core in the center. We conclude, that the seven-helix superhelical fold defines the ENTH domain, and that, the previously-reported eight-helix fold of a longer fragment of rat epsin, 1 is divided into the authentic ENTH domain and a C-terminal flanking, alpha-helix.
About this Structure
1INZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin., Koshiba S, Kigawa T, Kikuchi A, Yokoyama S, J Struct Funct Genomics. 2002;2(1):1-8. PMID:12836669
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