1jvv

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{{STRUCTURE_1jvv| PDB=1jvv | SCENE= }}
{{STRUCTURE_1jvv| PDB=1jvv | SCENE= }}
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'''CRYSTAL STRUCTURE OF RIBONUCLEASE A (RETRO-SOAKED FORM)'''
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===CRYSTAL STRUCTURE OF RIBONUCLEASE A (RETRO-SOAKED FORM)===
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==Overview==
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Despite the increasing number of successful determinations of complex protein structures the understanding of their dynamics properties is still rather limited. Using X-ray crystallography, we demonstrate that ribonuclease A (RNase A) undergoes significant domain motions upon ligand binding. In particular, when cytidine 2'-monophosphate binds to RNase A, the structure of the enzyme becomes more compact. Interestingly, our data also show that these structural alterations are fully reversible in the crystal state. These findings provide structural bases for the dynamic behavior of RNase A in the binding of the substrate shown by Petsko and coworkers (Rasmussen et al. Nature 1992;357:423-424). These subtle domain motions may assume functional relevance for more complex system and may play a significant role in the cooperativity of oligomeric enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 11746706 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11746706}}
==About this Structure==
==About this Structure==
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[[Category: Protein dynamic]]
[[Category: Protein dynamic]]
[[Category: Protein structure-function]]
[[Category: Protein structure-function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:59:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:01:56 2008''

Revision as of 18:02, 1 July 2008

Image:1jvv.png

Template:STRUCTURE 1jvv

CRYSTAL STRUCTURE OF RIBONUCLEASE A (RETRO-SOAKED FORM)

Template:ABSTRACT PUBMED 11746706

About this Structure

1JVV is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Reversible substrate-induced domain motions in ribonuclease A., Vitagliano L, Merlino A, Zagari A, Mazzarella L, Proteins. 2002 Jan 1;46(1):97-104. PMID:11746706

Page seeded by OCA on Tue Jul 1 21:01:56 2008

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