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1jwc

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[[Image:1jwc.gif|left|200px]]
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{{Seed}}
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[[Image:1jwc.png|left|200px]]
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{{STRUCTURE_1jwc| PDB=1jwc | SCENE= }}
{{STRUCTURE_1jwc| PDB=1jwc | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN'''
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===NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN===
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==Overview==
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The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism and regulation. We have determined the structure of the 26-nt sequence by multidimensional NMR spectroscopy. There is a 16-nt stem-loop motif, with a conserved 6-bp stem and a 4-nt loop. The loop is closed by a conserved U.A base pair that terminates the canonical A-form stem. The pyrimidine-rich 4-nt loop, UUUC, is well organized with the three uridines stacking on the helix, and the fourth base extending across the major groove into the solvent. The flanking nucleotides at the base of the hairpin stem do not assume a unique conformation, despite the fact that the 5' flanking nucleotides are a critical component of the SLBP binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11871662}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11871662 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11871662}}
==About this Structure==
==About this Structure==
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1JWC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA].
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1JWC is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA].
==Reference==
==Reference==
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[[Category: Hairpin]]
[[Category: Hairpin]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:05:02 2008''

Revision as of 18:05, 1 July 2008

Image:1jwc.png

Template:STRUCTURE 1jwc

NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN

Template:ABSTRACT PUBMED 11871662

About this Structure

1JWC is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:11871662

Page seeded by OCA on Tue Jul 1 21:05:02 2008

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