1jy1

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{{STRUCTURE_1jy1| PDB=1jy1 | SCENE= }}
{{STRUCTURE_1jy1| PDB=1jy1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)'''
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===CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)===
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==Overview==
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Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The enzyme appears to be responsible for repairing the unique protein-DNA linkage that occurs when eukaryotic topoisomerase I becomes stalled on the DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a monomer composed of two similar domains that are related by a pseudo-2-fold axis of symmetry. Each domain contributes conserved histidine, lysine, and asparagine residues to form a single active site. The structure of Tdp1 confirms that the protein has many similarities to the members of the phospholipase D (PLD) superfamily and indicates a similar catalytic mechanism. The structure also suggests how the unusual protein-DNA substrate binds and provides insights about the nature of the substrate in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 11839309 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11839309}}
==About this Structure==
==About this Structure==
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[[Category: Interthal, H.]]
[[Category: Interthal, H.]]
[[Category: Pld superfamily]]
[[Category: Pld superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:03:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:22:13 2008''

Revision as of 07:22, 28 July 2008

Image:1jy1.png

Template:STRUCTURE 1jy1

CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)

Template:ABSTRACT PUBMED 11839309

About this Structure

1JY1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1., Davies DR, Interthal H, Champoux JJ, Hol WG, Structure. 2002 Feb;10(2):237-48. PMID:11839309

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