CAMP-dependent protein kinase 3D structures

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**[[4ae6]], [[4ae9]] – hPKA 2 – human<br />
**[[4ae6]], [[4ae9]] – hPKA 2 – human<br />
 +
**[[8x5l]] – hPKA alpha
**[[1j3h]] – mPKA – mouse
**[[1j3h]] – mPKA – mouse
- 
**[[1syk]], [[4dfy]], [[4nts]] - mPKA (mutant)
**[[1syk]], [[4dfy]], [[4nts]] - mPKA (mutant)
- 
**[[6eh0]] – haPKA – hamster<br />
**[[6eh0]] – haPKA – hamster<br />
**[[1fot]] - yPKA – yeast<br />
**[[1fot]] - yPKA – yeast<br />
Line 16: Line 15:
*PKA catalytic subunit binary complex
*PKA catalytic subunit binary complex
-
**[[6c0u]], [[7y1g]] - hPKA + inhibitor<br />
+
**[[6c0u]], [[6you]], [[7y1g]] - hPKA + inhibitor<br />
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
**[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br />
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
**[[3bwj]] - bPKA + bisubstrate inhibitor<br />
**[[1szm]] - bPKA + bisindolymaleimide<br />
**[[1szm]] - bPKA + bisindolymaleimide<br />
-
**[[3ag9]] - bPKA + inhibitor<br />
+
**[[3ag9]], [[8sf8]] - bPKA + inhibitor<br />
**[[7lz4]] – bPKA (mutant) + CMP<br />
**[[7lz4]] – bPKA (mutant) + CMP<br />
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
**[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br />
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**[[6zn0]] - haPKA + nicotinamide derivative<br />
**[[6zn0]] - haPKA + nicotinamide derivative<br />
**[[6z08]], [[7bar]] - haPKA + ligand<br />
**[[6z08]], [[7bar]] - haPKA + ligand<br />
 +
**[[6yps]] - haPKA + inhibitor<br />
**[[4ntt]] – mPKA (mutant) + ADP<br />
**[[4ntt]] – mPKA (mutant) + ADP<br />
**[[1bkx]] – mPKA + adenosine<br />
**[[1bkx]] – mPKA + adenosine<br />
**[[3o7l]] – mPKA + phospholamban<br />
**[[3o7l]] – mPKA + phospholamban<br />
**[[1bx6]], [[1re8]], [[1rej]], [[1rek]] - mPKA + balanol analog<br />
**[[1bx6]], [[1re8]], [[1rej]], [[1rek]] - mPKA + balanol analog<br />
 +
**[[8ukn]] – mPKA + ANP<br />
*PKA catalytic subunit binary complex with peptide inhibitor
*PKA catalytic subunit binary complex with peptide inhibitor
-
**[[3mvj]], [[3oog]], [[3poo]], [[3vqh]], [[5j5x]], [[5izj]], [[5izf]], [[5bx7]], [[5bx6]], [[4ujb]], [[4uja]], [[4uj9]], [[4uj2]], [[4uj1]] - hPKA + peptide inhibitor<br />
+
**[[3mvj]], [[3oog]], [[3poo]], [[3vqh]], [[4uj1]], [[4uj2]], [[4uj9]], [[4uja]], [[4ujb]], [[5bx6]], [[5bx7]], [[5izf]], [[5izj]], [[5j5x]], [[7ujx]] - hPKA + peptide inhibitor<br />
 +
**[[9dw4]], [[9dw5]], [[9dw7]], [[9dw8]] - hPKA + CFTR peptide – Cryo EM<br />
**[[4z84]], [[4z83]] - hPKA (mutant) + peptide inhibitor<br />
**[[4z84]], [[4z83]] - hPKA (mutant) + peptide inhibitor<br />
**[[2gfc]], [[3dnd]], [[3dne]], [[3kkv]], [[3zo1]], [[3zo2]], [[3zo3]], [[3zo4]], [[4ie9]], [[4ij9]], [[4yxs]], [[4yxr]] - bPKA + peptide inhibitor<br />
**[[2gfc]], [[3dnd]], [[3dne]], [[3kkv]], [[3zo1]], [[3zo2]], [[3zo3]], [[3zo4]], [[4ie9]], [[4ij9]], [[4yxs]], [[4yxr]] - bPKA + peptide inhibitor<br />
**[[2gng]], [[4axa]], [[4c33]], [[4c34]], [[4c35]], [[4c36]], [[4c37]], [[4c38]] - bPKA (mutant) + peptide inhibitor<br />
**[[2gng]], [[4axa]], [[4c33]], [[4c34]], [[4c35]], [[4c36]], [[4c37]], [[4c38]] - bPKA (mutant) + peptide inhibitor<br />
**[[1cdk]] - pPKA + peptide inhibitor – pig<br />
**[[1cdk]] - pPKA + peptide inhibitor – pig<br />
-
**[[2cpk]], [[1ctp]], [[1fmo]], [[1l3r]], [[1xh4]], [[1xh5]], [[1xh6]], [[1xh7]], [[1xh8]], [[1xh9]], [[1xha]], [[3fjq]], [[4dg0]], [[4dg2]], [[4dh1]], [[4dh3]], [[4dh5]], [[4dh7]], [[4dh8]], [[4hpt]], [[4hpu]], [[4xw6]], [[4xw5]], [[4xw4]], [[3x2w]], [[3x2v]], [[3x2u]] – mPKA + peptide inhibitor<br />
+
**[[1ctp]], [[1fmo]], [[1l3r]], [[1xh4]], [[1xh5]], [[1xh6]], [[1xh7]], [[1xh8]], [[1xh9]], [[1xha]], [[3fjq]], [[3x2u]], [[3x2v]], [[3x2w]], [[4dg0]], [[4dg2]], [[4dh1]], [[4dh3]], [[4dh5]], [[4dh7]], [[4dh8]], [[4hpt]], [[4hpu]], [[4xw6]], [[4xw5]], [[4xw4]] – mPKA + peptide inhibitor<br />
**[[1q61]], [[1q62]], [[1smh]], [[2qur]], [[3qal]], [[3qam]], [[4dfx]], [[4dfz]], [[4dg3]] - mPKA (mutant) + peptide inhibitor<br />
**[[1q61]], [[1q62]], [[1smh]], [[2qur]], [[3qal]], [[3qam]], [[4dfx]], [[4dfz]], [[4dg3]] - mPKA (mutant) + peptide inhibitor<br />
**[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]] - mPKA + PSP20 peptide<br />
**[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]] - mPKA + PSP20 peptide<br />
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**[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br />
**[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br />
**[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br />
**[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br />
-
**[[6y2u]], [[6yna]], [[6ynb]], [[6ync]], [[6ynt]], [[6ypp]], [[6yqi]], [[6yqj]], [[6yqk]] – haPKA + PKI peptide + drug<br />
+
**[[6wjf]], [[6wjg]] - rPKA + DNAJ B1 Cryo EM<br />
-
**[[6y0b]], [[6y2o]], [[6y89]], [[6ynr]], [[6yot]] haPKA + PKI peptide + inhibitor<br />
+
*PKA catalytic subunit ternary complex
*PKA catalytic subunit ternary complex
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**[[2gu8]], [[3l9l]], [[3ovv]], [[3owp]], [[3oxt]], [[3p0m]], [[5uzk]] - hPKA catalytic subunit + peptide inhibitor + inhibitor<br />
**[[2gu8]], [[3l9l]], [[3ovv]], [[3owp]], [[3oxt]], [[3p0m]], [[5uzk]] - hPKA catalytic subunit + peptide inhibitor + inhibitor<br />
**[[3nx8]] - hPKA catalytic subunit + peptide inhibitor + phenol<br />
**[[3nx8]] - hPKA catalytic subunit + peptide inhibitor + phenol<br />
-
**[[3l9m]], [[3l9n]], [[3ama]], [[3amb]] - hPKA (mutant) + peptide inhibitor + inhibitor<br />
+
**[[3ama]], [[3amb], [[3l9m]], [[3l9n]] - hPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[3wyg]] – hPKA + GSP1P + exportin<br />
**[[3wyg]] – hPKA + GSP1P + exportin<br />
**[[6qj7]] – hPKA + PKI + inhibitor<br />
**[[6qj7]] – hPKA + PKI + inhibitor<br />
**[[1stc]] - bPKA + peptide inhibitor + saturosporine<br />
**[[1stc]] - bPKA + peptide inhibitor + saturosporine<br />
**[[2gnh]], [[2gni]], [[2gnj]], [[2gnl]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[2gnh]], [[2gni]], [[2gnj]], [[2gnl]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
-
**[[1ydr]], [[1yds]], [[1ydt]], [[2c1a]], [[2c1b]], [[2oh0]], [[2ojf]], [[2uzt]], [[2uzu]], [[2uzv]], [[2uzw]], [[2f7e]], [[2f7x]], [[2f7z]], [[2jds]], [[5vib]], [[6e99]], [[6e9l]], [[5vhb]] - bPKA + peptide inhibitor + inhibitor<br />
+
**[[1ydr]], [[1yds]], [[1ydt]], [[2c1a]], [[2c1b]], [[2f7e]], [[2f7x]], [[2f7z]], [[2jds]], [[2oh0]], [[2ojf]], [[2uzt]], [[2uzu]], [[2uzv]], [[2uzw]], [[5vhb]], [[5vi9]], [[5vib]], [[6e99]], [[6e9l]] - bPKA + peptide inhibitor + inhibitor
 +
**[[2gnh,]] [[2gni]], [[2gnj]], [[2gnl]], [[2jdt]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor
**[[2jdt]], [[5vi9]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[2jdt]], [[5vi9]] - bPKA (mutant) + peptide inhibitor + inhibitor<br />
**[[3e8c]], [[3e8e]] - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor<br />
**[[3e8c]], [[3e8e]] - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor<br />
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**[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br />
**[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br />
**[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br />
**[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br />
-
**[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6i2h]], [[6i2d]], [[6i2b]], [[6eh3]], [[6egw]], [[5ous]], [[5ouc]], [[5oua]], [[5otg]], [[5ot3]], [[5ol3]], [[5ok3]], [[5o5m]], [[5o0e]], [[5nw8]], [[5ntj]] - haPKA + peptide inhibitor + inhibitor<br />
+
**[[5ntj]], [[5nw8]], [[5o0e]], [[5o5m]], [[5ok3]], [[5ol3]], [[5ot3]], [[5otg]], [[5oua]], [[5ouc]], [[5ous]], [[6egw]], [[6eh3]], [[6emc]], [[6emd]], [[6eme]], [[6ert]], [[6eru]], [[6erv]], [[6f14]], [[6frx]], [[6y0b]], [[6y2o]], [[6y89]], [[6ynr]], [[6yot]] - haPKA + peptide inhibitor + inhibitor<br />
-
**[[6erw]], [[6i2c]], [[6i2a]], [[5m75]], [[5m71]], [[5m6y]], [[5m6v]], [[5m0l]], [[5m0c]], [[5m0b]] - haPKA + peptide inhibitor + drug<br />
+
**[[5m0b]], [[5m0c]], [[5m0l]], [[5m6v]], [[5m6y]], [[5m71]], [[5m75]], [[6emb]], [[6ers]], [[6erw]], [[6y2u]], [[6yna]], [[6ynb]], [[6ync]], [[6ynt]], [[6ypp]], [[6yqi]], [[6yqj]], [[6yqk]] - haPKA + peptide inhibitor + drug<br />
**[[6i2a]] - haPKA + RPK153 + drug <br />
**[[6i2a]] - haPKA + RPK153 + drug <br />
**[[6i2c]], [[6i2d]] - haPKA + RPK182 + drug <br />
**[[6i2c]], [[6i2d]] - haPKA + RPK182 + drug <br />
**[[7axt]], [[7axv]], [[7axw]], [[7baq]], [[7bb0]], [[7pid]], [[7pie]], [[7pif]], [[7pig]], [[7pih]], [[7pns]] - haPKA + PKI + ligand<br />
**[[7axt]], [[7axv]], [[7axw]], [[7baq]], [[7bb0]], [[7pid]], [[7pie]], [[7pif]], [[7pig]], [[7pih]], [[7pns]] - haPKA + PKI + ligand<br />
-
*PKA catalytic subunit ternary complex with nucleotide
+
*PKA catalytic subunit higher complex with nucleotide
**[[1q24]] - bPKA + peptide inhibitor + Mg-ATP<br />
**[[1q24]] - bPKA + peptide inhibitor + Mg-ATP<br />
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**[[4o21]] - mPKA + peptide inhibitor + ATP-G-S<br />
**[[4o21]] - mPKA + peptide inhibitor + ATP-G-S<br />
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
**[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br />
-
**[[6e21]] - mPKA + peptide inhibitor + ADP<br />
+
**[[6e21]], [[7v0g]] - mPKA + peptide inhibitor + ADP<br />
 +
**[[8uko]], [[8ukp]] – mPKA + Ca channel peptide + ANP<br />
**[[7e0z]], [[7e11]], [[7e12]] - mPKA + PLN peptide + PPNP<br />
**[[7e0z]], [[7e11]], [[7e12]] - mPKA + PLN peptide + PPNP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
**[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br />
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*PKA regulatory subunit binary complex
*PKA regulatory subunit binary complex
-
**[[2izx]], [[2izy]], [[4zp3]] - hPKA II-α + A-kinase anchoring protein peptide<br />
 
-
**[[2kyg]] - hPKA II-α + CBFA2T1<br />
 
**[[5kjx]] - hPKA I-α + cAMP<br />
**[[5kjx]] - hPKA I-α + cAMP<br />
**[[5kjy]], [[5kjz]] - hPKA I-α (mutant) + cAMP<br />
**[[5kjy]], [[5kjz]] - hPKA I-α (mutant) + cAMP<br />
 +
**[[2izx]], [[2izy]], [[4zp3]] - hPKA II-α + A-kinase anchoring protein peptide
 +
**[[2kyg]] - hPKA II-α + CBFA2T1
 +
**[[8s8o]] - hPKA II-α + microtubule-associated protein 2 80-120 - NMR
**[[3im4]], [[5hvz]] - bPKA I-α + A-kinase anchoring protein peptide<br />
**[[3im4]], [[5hvz]] - bPKA I-α + A-kinase anchoring protein peptide<br />
**[[4jv4]] – bPKA I-α + cAMP analog<br />
**[[4jv4]] – bPKA I-α + cAMP analog<br />

Revision as of 10:45, 29 December 2024

3D structures of cAMP-dependent protein kinase

Updated on 29-December-2024 {{#tree:id=OrganizedByTopic|openlevels=0|

  • PKA catalytic subunit
  • PKA catalytic subunit binary complex
  • PKA catalytic subunit binary complex with peptide inhibitor
  • PKA catalytic subunit ternary complex
  • PKA catalytic subunit higher complex with nucleotide
    • 1q24 - bPKA + peptide inhibitor + Mg-ATP
    • 1jbp - mPKA + detergent + peptide inhibitor + ADP
    • 1rdq - mPKA + peptide inhibitor + ADP + ATP
    • 4o21 - mPKA + peptide inhibitor + ATP-G-S
    • 1atp - mPKA + peptide inhibitor + Mn-ATP
    • 6e21, 7v0g - mPKA + peptide inhibitor + ADP
    • 8uko, 8ukp – mPKA + Ca channel peptide + ANP
    • 7e0z, 7e11, 7e12 - mPKA + PLN peptide + PPNP
    • 6em7, 6em6 - haPKA + peptide inhibitor + inhibitor + ADP
    • 6eh2 - haPKA + peptide inhibitor + inhibitor + AMP
    • 6esa - haPKA + peptide inhibitor + ribose + AMP
    • 6ema - haPKA + peptide inhibitor + inhibitor + ATP
    • 6y8c – haPKA + PKI peptide + ATP
    • 6y05 – haPKA + PKI peptide + Adenine
  • PKA regulatory subunit
    • 4f9k – hPKA I-β
    • 1ne4, 1ne6, 1rl3, 3iia, 1rgs, 4mx3 - bPKA
    • 2ezw - bPKA I-α dimerization-anchoring domain - NMR
    • 3im3 - bPKA I-α dimerization-anchoring domain
    • 3pna - bPKA I-α cAMP-binding domain
    • 1cx4 - rPKA II-β cAMP-binding domain – rat
    • 1r2a - mPKA II dimerization-anchoring domain – NMR
    • 1l6e - mPKA II-α dimerization-anchoring domain – NMR
    • 3of1, 6xqk - yPKA
  • PKA regulatory subunit binary complex
    • 5kjx - hPKA I-α + cAMP
    • 5kjy, 5kjz - hPKA I-α (mutant) + cAMP
    • 2izx, 2izy, 4zp3 - hPKA II-α + A-kinase anchoring protein peptide
    • 2kyg - hPKA II-α + CBFA2T1
    • 8s8o - hPKA II-α + microtubule-associated protein 2 80-120 - NMR
    • 3im4, 5hvz - bPKA I-α + A-kinase anchoring protein peptide
    • 4jv4 – bPKA I-α + cAMP analog
    • 3plq - bPKA I-α + cAMP derivative
    • 2hwn - rPKA II-α + A-kinase binding peptide
    • 4jva – rPKA II-β + cAMP analog
    • 2drn, 2h9r - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR
    • 5t3n - PfPKA + cAMP derivative – Plasmodium falciparum
    • 5kbf, 5k8s - PfPKA + cAMP
    • 6h4g - PKA (mutant) + cAMP – Trypanosoma brucei
    • 6rsx - PKA + cAMP – Euglena gracilis
  • PKA regulatory subunit ternary complex
    • 3tmh - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3
    • 8em8 - PfPKA + peptide + inhibitor
  • PKA catalytic and regulatory subunits

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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