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8hgv

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'''Unreleased structure'''
 
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The entry 8hgv is ON HOLD
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==Crystal structure of monoalkyl phthalate hydrolase MehpH==
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<StructureSection load='8hgv' size='340' side='right'caption='[[8hgv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hgv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gordonia Gordonia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HGV FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hgv OCA], [https://pdbe.org/8hgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hgv RCSB], [https://www.ebi.ac.uk/pdbsum/8hgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hgv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q2MHH5_9ACTN Q2MHH5_9ACTN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phthalate acid esters (PAEs), a group of xenobiotic compounds used extensively as plasticizers, have attracted increasing concern for adverse effects to human health and the environment. Microbial degradation relying on PAE hydrolases is a promising treatment. However, only a limited number of PAE hydrolases were characterized to date. Here we report the structures of MehpH, a monoalkyl phthalate (MBP) hydrolase that catalyzes the reaction of MBP to phthalic acid and the corresponding alcohol, in apo and ligand-bound form. The structures reveal a positively-charged catalytic center, complementary to the negatively-charged carboxyl group on MBP, and a penetrating tunnel that serves as exit of alcohol. The study provides a first glimpse into the enzyme-substrate binding model for PAE hydrolases, leading strong support to the development of better enzymes in the future.
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Authors: Zhang, Z.M., Wang, Y.J., Chen, Y.B.
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Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase.,Chen Y, Wang Y, Xu Y, Sun J, Yang L, Feng C, Wang J, Zhou Y, Zhang ZM, Wang Y Commun Chem. 2023 Mar 1;6(1):45. doi: 10.1038/s42004-023-00846-0. PMID:36859434<ref>PMID:36859434</ref>
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Description: Crystal structure of monoalkyl phthalate hydrolase MehpH
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Chen, Y.B]]
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<div class="pdbe-citations 8hgv" style="background-color:#fffaf0;"></div>
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[[Category: Wang, Y.J]]
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== References ==
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[[Category: Zhang, Z.M]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gordonia]]
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[[Category: Large Structures]]
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[[Category: Chen YB]]
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[[Category: Wang YJ]]
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[[Category: Zhang ZM]]

Revision as of 09:54, 15 March 2023

Crystal structure of monoalkyl phthalate hydrolase MehpH

PDB ID 8hgv

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