1jzo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jzo.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1jzo.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jzo| PDB=1jzo | SCENE= }}
{{STRUCTURE_1jzo| PDB=1jzo | SCENE= }}
-
'''DsbC C101S'''
+
===DsbC C101S===
-
==Overview==
+
<!--
-
The Escherichia coli disulfide bond isomerase DsbC rearranges incorrect disulfide bonds during oxidative protein folding. It is specifically activated by the periplasmic N-terminal domain (DsbDalpha) of the transmembrane electron transporter DsbD. An intermediate of the electron transport reaction was trapped, yielding a covalent DsbC-DsbDalpha complex. The 2.3 A crystal structure of the complex shows for the first time the specific interactions between two thiol oxidoreductases. DsbDalpha is a novel thiol oxidoreductase with the active site cysteines embedded in an immunoglobulin fold. It binds into the central cleft of the V-shaped DsbC dimer, which assumes a closed conformation on complex formation. Comparison of the complex with oxidized DsbDalpha reveals major conformational changes in a cap structure that regulates the accessibility of the DsbDalpha active site. Our results explain how DsbC is selectively activated by DsbD using electrons derived from the cytoplasm.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12234918}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12234918 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12234918}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Thiol oxidoreductase]]
[[Category: Thiol oxidoreductase]]
[[Category: Thioredoxin fold]]
[[Category: Thioredoxin fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:07:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:39 2008''

Revision as of 16:50, 28 July 2008

Image:1jzo.png

Template:STRUCTURE 1jzo

DsbC C101S

Template:ABSTRACT PUBMED 12234918

About this Structure

1JZO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex., Haebel PW, Goldstone D, Katzen F, Beckwith J, Metcalf P, EMBO J. 2002 Sep 16;21(18):4774-84. PMID:12234918

Page seeded by OCA on Mon Jul 28 19:50:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jzo"
Personal tools