This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4qvj
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QVJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_cat/GIV.2/CU081210E/USA/2010 Norovirus cat/GIV.2/CU081210E/USA/2010]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QVJ FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qvj OCA], [https://pdbe.org/4qvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qvj RCSB], [https://www.ebi.ac.uk/pdbsum/4qvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qvj ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qvj OCA], [https://pdbe.org/4qvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qvj RCSB], [https://www.ebi.ac.uk/pdbsum/4qvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qvj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI] | [https://www.uniprot.org/uniprot/H8YRY9_9CALI H8YRY9_9CALI] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35A resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain alpha-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus. | ||
| - | |||
| - | Structural analysis of a feline norovirus protruding domain.,Singh BK, Glatt S, Ferrer JL, Koromyslova AD, Leuthold MM, Dunder J, Hansman GS Virology. 2015 Jan 1;474:181-5. doi: 10.1016/j.virol.2014.10.028. Epub 2014 Nov, 19. PMID:25463616<ref>PMID:25463616</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4qvj" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with N-acetylneuraminic acid
| |||||||||||
