8bp8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==SPA of Trypsin untreated Rotavirus TLP spike== | |
| - | + | <StructureSection load='8bp8' size='340' side='right'caption='[[8bp8]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bp8]] is a 31 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BP8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bp8 OCA], [https://pdbe.org/8bp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bp8 RCSB], [https://www.ebi.ac.uk/pdbsum/8bp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bp8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A2T3S6_9VIRU A2T3S6_9VIRU] Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.[HAMAP-Rule:MF_04129] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rotavirus A]] | ||
| + | [[Category: Shah PNM]] | ||
| + | [[Category: Stuart DI]] | ||
Revision as of 06:27, 7 April 2023
SPA of Trypsin untreated Rotavirus TLP spike
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