8hsc

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'''Unreleased structure'''
 
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The entry 8hsc is ON HOLD until Paper Publication
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==Gi bound Orphan GPR20 complex with Fab046 in ligand-free state==
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<StructureSection load='8hsc' size='340' side='right'caption='[[8hsc]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
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Authors: Lin, X., Jiang, S., Xu, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hsc]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus Rattus] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HSC FirstGlance]. <br>
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Description: Gi bound Orphan GPR20 complex with Fab046 in ligand-free state
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hsc OCA], [https://pdbe.org/8hsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hsc RCSB], [https://www.ebi.ac.uk/pdbsum/8hsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hsc ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Xu, F]]
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== Function ==
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[[Category: Jiang, S]]
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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[[Category: Lin, X]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Rattus]]
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[[Category: Vicugna pacos]]
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[[Category: Jiang S]]
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[[Category: Lin X]]
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[[Category: Xu F]]

Revision as of 07:38, 8 March 2023

Gi bound Orphan GPR20 complex with Fab046 in ligand-free state

PDB ID 8hsc

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