This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k2a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k2a.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k2a.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k2a| PDB=1k2a | SCENE= }}
{{STRUCTURE_1k2a| PDB=1k2a | SCENE= }}
-
'''Modified Form of Eosinophil-derived Neurotoxin'''
+
===Modified Form of Eosinophil-derived Neurotoxin===
-
==Overview==
+
<!--
-
The crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A). Two of the extra residues can be placed unambiguously, while the density corresponding to two others is poor. The modified N terminus appears to influence the position of the catalytically important His129, possibly explaining the diminished catalytic activity of this variant. However, (-4)EDN has been shown to be cytotoxic to a Kaposi's sarcoma tumor cell line and other endothelial cell lines. Analysis of the structure and function suggests that the reason for cytotoxicity is most likely due to cellular recognition by the N-terminal extension, since the intrinsic activity of the enzyme is not sufficient for cytotoxicity and the N-terminal extension does not affect the conformation of EDN.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11916383}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11916383 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11916383}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Rnase a folding]]
[[Category: Rnase a folding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:26:11 2008''

Revision as of 18:26, 1 July 2008

Image:1k2a.png

Template:STRUCTURE 1k2a

Modified Form of Eosinophil-derived Neurotoxin

Template:ABSTRACT PUBMED 11916383

About this Structure

1K2A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities., Chang C, Newton DL, Rybak SM, Wlodawer A, J Mol Biol. 2002 Mar 15;317(1):119-30. PMID:11916383

Page seeded by OCA on Tue Jul 1 21:26:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k2a"
Personal tools