This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k2d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k2d.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1k2d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k2d| PDB=1k2d | SCENE= }}
{{STRUCTURE_1k2d| PDB=1k2d | SCENE= }}
-
'''Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A'''
+
===Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A===
-
==Overview==
+
<!--
-
Murine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating, autoimmune disease multiple sclerosis. In the EAE system, the immunodominant N-terminal epitope of myelin basic protein (MBP) is an unusually short, weakly binding peptide antigen which elicits highly biased TCR chain usage. In the 2.2 A crystal structure of I-A(u)/MBP1-11 complex, only MBP residues 1-7 are bound toward one end of the peptide binding cleft. The fourth residue of MBP1-11 is located in an incompatible p6 pocket of I-A(u), thus explaining the short half-life of I-A(u) complexed with Ac1-11. MBP peptides extended at the C terminus of Ac1-11 result in dramatic affinity increases, likely attributed to register shifting to a higher affinity cryptic epitope, which could potentially mask the presentation of the immunodominant MBP1-11 peptide during thymic education.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12150894}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12150894 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12150894}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Myelin basic protein]]
[[Category: Myelin basic protein]]
[[Category: Unique register]]
[[Category: Unique register]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:56 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:27:52 2008''

Revision as of 18:28, 1 July 2008

Image:1k2d.png

Template:STRUCTURE 1k2d

Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A

Template:ABSTRACT PUBMED 12150894

About this Structure

1K2D is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au., He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC, Immunity. 2002 Jul;17(1):83-94. PMID:12150894

Page seeded by OCA on Tue Jul 1 21:27:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k2d"
Personal tools