1k2l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k2l.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k2l.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k2l| PDB=1k2l | SCENE= }}
{{STRUCTURE_1k2l| PDB=1k2l | SCENE= }}
-
'''STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX'''
+
===STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX===
-
==Overview==
+
<!--
-
We report the single-crystal X-ray structure for the complex of the bisacridine bis-(9-aminooctyl(2-(dimethylaminoethyl)acridine-4-carboxamide)) with the oligonucleotide d(CGTACG)(2) to a resolution of 2.4A. Solution studies with closed circular DNA show this compound to be a bisintercalating threading agent, but so far we have no crystallographic or NMR structural data conforming to the model of contiguous intercalation within the same duplex. Here, with the hexameric duplex d(CGTACG), the DNA is observed to undergo a terminal cytosine base exchange to yield an unusual guanine quadruplex intercalation site through which the bisacridine threads its octamethylene linker to fuse two DNA duplexes. The 4-carboxamide side-chains form anchoring hydrogen-bonding interactions with guanine O6 atoms on each side of the quadruplex. This higher-order DNA structure provides insight into an unexpected property of bisintercalating threading agents, and suggests the idea of targeting such compounds specifically at four-way DNA junctions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12381312}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12381312 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12381312}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Dna strand exchange]]
[[Category: Dna strand exchange]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:35:33 2008''

Revision as of 18:35, 1 July 2008

Image:1k2l.png

Template:STRUCTURE 1k2l

STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX

Template:ABSTRACT PUBMED 12381312

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex., Teixeira SC, Thorpe JH, Todd AK, Powell HR, Adams A, Wakelin LP, Denny WA, Cardin CJ, J Mol Biol. 2002 Oct 18;323(2):167-71. PMID:12381312

Page seeded by OCA on Tue Jul 1 21:35:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k2l"
Personal tools