1k2o

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{{STRUCTURE_1k2o| PDB=1k2o | SCENE= }}
{{STRUCTURE_1k2o| PDB=1k2o | SCENE= }}
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'''Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)'''
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===Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)===
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==Overview==
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Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the active center via a 22-A deep channel. Interactions of alkyl and fluorinated biphenyl linkers with the channel demonstrate the importance of exploiting protein dynamics for specific inhibitor design. Large changes in peripheral enzyme structure (F and G helices) couple to conformational changes in active center residues (I helix) implicated in proton pumping and dioxygen activation. Common conformational states among P450cam and homologous enzymes indicate that static and dynamic variability in the F/G helix region allows the 54 human P450s to oxidize thousands of substrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 11606730 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11606730}}
==About this Structure==
==About this Structure==
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[[Category: Ruthenium channel]]
[[Category: Ruthenium channel]]
[[Category: Substrate-binding]]
[[Category: Substrate-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:36:53 2008''

Revision as of 18:37, 1 July 2008

Image:1k2o.png

Template:STRUCTURE 1k2o

Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)

Template:ABSTRACT PUBMED 11606730

About this Structure

1K2O is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Probing the open state of cytochrome P450cam with ruthenium-linker substrates., Dunn AR, Dmochowski IJ, Bilwes AM, Gray HB, Crane BR, Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12420-5. Epub 2001 Oct 16. PMID:11606730

Page seeded by OCA on Tue Jul 1 21:36:53 2008

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