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1k2p

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{{STRUCTURE_1k2p| PDB=1k2p | SCENE= }}
{{STRUCTURE_1k2p| PDB=1k2p | SCENE= }}
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'''Crystal structure of Bruton's tyrosine kinase domain'''
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===Crystal structure of Bruton's tyrosine kinase domain===
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==Overview==
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Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided.
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(as it appears on PubMed at http://www.pubmed.gov), where 11527964 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11527964}}
==About this Structure==
==About this Structure==
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[[Category: Bruton tryosine kinase]]
[[Category: Bruton tryosine kinase]]
[[Category: Kinase domain]]
[[Category: Kinase domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:38:47 2008''

Revision as of 18:39, 1 July 2008

Image:1k2p.png

Template:STRUCTURE 1k2p

Crystal structure of Bruton's tyrosine kinase domain

Template:ABSTRACT PUBMED 11527964

About this Structure

1K2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia., Mao C, Zhou M, Uckun FM, J Biol Chem. 2001 Nov 2;276(44):41435-43. Epub 2001 Aug 29. PMID:11527964

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