1k2w

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{{STRUCTURE_1k2w| PDB=1k2w | SCENE= }}
{{STRUCTURE_1k2w| PDB=1k2w | SCENE= }}
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'''Crystal structure of sorbitol dehydrogenase from R. sphaeroides'''
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===Crystal structure of sorbitol dehydrogenase from R. sphaeroides===
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==Overview==
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Recombinant sorbitol dehydrogenase (SDH) from Rhodobacter sphaeroides has been crystallized in the absence of the cofactor NAD(H) and its structure determined to 2.4 A resolution using molecular replacement (refined R and R free factors of 18.8 and 23.8%, respectively). As expected from the sequence and shown by the conserved fold, SDH can be assigned to the short-chain dehydrogenase/reductase protein family. The cofactor NAD and the substrate sorbitol have been modelled into the structure and the active-site architecture, which displays the highly conserved catalytic tetrad of Asn-Ser-Tyr-Lys residues, is discussed in relation to the enzyme mechanism. This is the first structure of a bacterial SDH belonging to the SDR family.
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(as it appears on PubMed at http://www.pubmed.gov), where 15805591 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15805591}}
==About this Structure==
==About this Structure==
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[[Category: Enzyme]]
[[Category: Enzyme]]
[[Category: Short-chain dehydrogenase]]
[[Category: Short-chain dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:54:19 2008''

Revision as of 18:54, 1 July 2008

Image:1k2w.png

Template:STRUCTURE 1k2w

Crystal structure of sorbitol dehydrogenase from R. sphaeroides

Template:ABSTRACT PUBMED 15805591

About this Structure

1K2W is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution., Philippsen A, Schirmer T, Stein MA, Giffhorn F, Stetefeld J, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):374-9. Epub 2005, Mar 24. PMID:15805591

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