4rm0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4rm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RM0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4rm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RM0 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900129:Lewis+A+antigen,+beta+anomer'>PRD_900129</scene>, <scene name='pdbligand=PRD_900130:Lewis+A+antigen,+alpha+anomer'>PRD_900130</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.999Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900129:Lewis+A+antigen,+beta+anomer'>PRD_900129</scene>, <scene name='pdbligand=PRD_900130:Lewis+A+antigen,+alpha+anomer'>PRD_900130</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rm0 OCA], [https://pdbe.org/4rm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rm0 RCSB], [https://www.ebi.ac.uk/pdbsum/4rm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rm0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rm0 OCA], [https://pdbe.org/4rm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rm0 RCSB], [https://www.ebi.ac.uk/pdbsum/4rm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rm0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q6B7R3_9CALI Q6B7R3_9CALI] | [https://www.uniprot.org/uniprot/Q6B7R3_9CALI Q6B7R3_9CALI] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Norovirus (NoV) causes epidemic acute gastroenteritis in humans, whereby histo-blood group antigens (HBGAs) play an important role in host susceptibility. Each of the two major genogroups (GI and GII) of human NoVs recognizes a unique set of HBGAs through a distinct binding interface that is conserved within a genogroup, indicating a distinct evolutionary path for each genogroup. Here, we characterize a Lewis a (Lea) antigen binding strain (OIF virus) in the GII.21 genotype that does not share the conserved GII binding interface, revealing a new evolution lineage with a distinct HBGA binding interface. Sequence alignment showed that the major residues contributing to the new HBGA binding interface are conserved among most members of the GII.21, as well as a closely related GII.13 genotype. In addition, we found that glycerol inhibits OIF binding to HBGAs, potentially allowing production of cheap antivirals against human NoVs. Taken together, our results reveal a new evolutionary lineage of NoVs selected by HBGAs, a finding that is important for understanding the diversity and widespread nature of NoVs. | ||
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| - | A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface.,Liu W, Chen Y, Jiang X, Xia M, Yang Y, Tan M, Li X, Rao Z PLoS Pathog. 2015 Jul 6;11(7):e1005025. doi: 10.1371/journal.ppat.1005025., eCollection 2015 Jul. PMID:26147716<ref>PMID:26147716</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4rm0" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of Norovirus OIF P domain in complex with Lewis a trisaccharide
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Categories: Large Structures | Norovirus NLV/IF1998/2003/Iraq | Chen Y | Jiang X | Li X | Liu W | Rao Z | Tan M | Xia M
