1k3i

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{{STRUCTURE_1k3i| PDB=1k3i | SCENE= }}
{{STRUCTURE_1k3i| PDB=1k3i | SCENE= }}
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'''Crystal Structure of the Precursor of Galactose Oxidase'''
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===Crystal Structure of the Precursor of Galactose Oxidase===
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==Overview==
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Galactose oxidase (EC ) is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes. The protein contains an unusual covalent thioether bond between a tyrosine, which acts as a radical center during the two-electron reaction, and a cysteine. The enzyme is produced in a precursor form lacking the thioether bond and also possessing an additional 17-aa pro-sequence at the N terminus. Previous work has shown that the aerobic addition of Cu(2+) to the precursor is sufficient to generate fully processed mature enzyme. The structure of the precursor protein has been determined to 1.4 A, revealing the location of the pro-sequence and identifying structural differences between the precursor and the mature protein. Structural alignment of the precursor and mature forms of galactose oxidase shows that five regions of main chain and some key residues of the active site differ significantly between the two forms. The precursor structure provides a starting point for modeling the chemistry of thioether bond formation and pro-sequence cleavage.
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The line below this paragraph, {{ABSTRACT_PUBMED_11698678}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11698678 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11698678}}
==About this Structure==
==About this Structure==
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[[Category: Precursor of copper enzyme.]]
[[Category: Precursor of copper enzyme.]]
[[Category: Prosequence form]]
[[Category: Prosequence form]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:15:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:29:58 2008''

Revision as of 09:30, 28 July 2008

Image:1k3i.png

Template:STRUCTURE 1k3i

Crystal Structure of the Precursor of Galactose Oxidase

Template:ABSTRACT PUBMED 11698678

About this Structure

1K3I is a Single protein structure of sequence from Fusarium sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of the precursor of galactose oxidase: an unusual self-processing enzyme., Firbank SJ, Rogers MS, Wilmot CM, Dooley DM, Halcrow MA, Knowles PF, McPherson MJ, Phillips SE, Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12932-7. PMID:11698678

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