This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8cgy
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; XDS processing== | |
| - | + | <StructureSection load='8cgy' size='340' side='right'caption='[[8cgy]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8cgy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CGY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cgy OCA], [https://pdbe.org/8cgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cgy RCSB], [https://www.ebi.ac.uk/pdbsum/8cgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cgy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IMDH_TRYBB IMDH_TRYBB] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei]] | ||
| + | [[Category: Boger J]] | ||
| + | [[Category: Bourenkov G]] | ||
| + | [[Category: Duden R]] | ||
| + | [[Category: Harms M]] | ||
| + | [[Category: Kaiser J]] | ||
| + | [[Category: Lahey-Rudolph JM]] | ||
| + | [[Category: Nachtschatt S]] | ||
| + | [[Category: Redecke L]] | ||
| + | [[Category: Schneider T]] | ||
| + | [[Category: Schoenherr R]] | ||
| + | [[Category: Wobbe M]] | ||
Current revision
Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; XDS processing
| |||||||||||
Categories: Large Structures | Trypanosoma brucei | Boger J | Bourenkov G | Duden R | Harms M | Kaiser J | Lahey-Rudolph JM | Nachtschatt S | Redecke L | Schneider T | Schoenherr R | Wobbe M
