1k4d

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[[Image:1k4d.gif|left|200px]]
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{{Seed}}
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[[Image:1k4d.png|left|200px]]
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{{STRUCTURE_1k4d| PDB=1k4d | SCENE= }}
{{STRUCTURE_1k4d| PDB=1k4d | SCENE= }}
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'''Potassium Channel KcsA-Fab complex in low concentration of K+'''
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===Potassium Channel KcsA-Fab complex in low concentration of K+===
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==Overview==
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Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 A resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entryway. Carbonyl oxygen atoms within the selectivity filter form a very similar square antiprism around each K+ binding site, as if to mimic the waters of hydration. The selectivity filter changes its ion coordination structure in low K+ solutions. This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating.
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The line below this paragraph, {{ABSTRACT_PUBMED_11689936}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11689936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11689936}}
==About this Structure==
==About this Structure==
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[[Category: K channel]]
[[Category: K channel]]
[[Category: Protein-antibody fab complex]]
[[Category: Protein-antibody fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:17:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 08:17:07 2008''

Revision as of 06:41, 2 July 2008

Image:1k4d.png

Template:STRUCTURE 1k4d

Potassium Channel KcsA-Fab complex in low concentration of K+

Template:ABSTRACT PUBMED 11689936

About this Structure

1K4D is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution., Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R, Nature. 2001 Nov 1;414(6859):43-8. PMID:11689936

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