Sandbox Reserved 1770
From Proteopedia
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| - | + | =Sodium-taurocholate Co-transporting Polypeptide= | |
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| - | <StructureSection load=' | + | <StructureSection load='7PQQ' size='350' side='right' frame='true' caption='Sodium-taurocholate co-transporting Polypeptide (NTCP) 7PQQ' scene=''> |
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== Introduction == | == Introduction == | ||
| + | Sodium-taurocholate Co-transporting Polypeptide (NTCP) is found within the membrane of [https://en.wikipedia.org/wiki/Hepatocyte hepatocyte], and its primary role is to facilitate the transport of [https://en.wikipedia.org/wiki/Bile_acid bile salts] into hepatocytes from the bloodstream. This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile salts to solubilize fats for digestion. In addition to transporting bile salts into the cytoplasm of hepatocytes, NTCP also serves as a receptor for [https://en.wikipedia.org/wiki/Hepatitis_B Hepatitis B (HBV)] and [https://en.wikipedia.org/wiki/Hepatitis_D Hepatitis D (HDV)] viruses. | ||
== Function == | == Function == | ||
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== Structure == | == Structure == | ||
| - | === | + | === Proline/Glycine Hinge === |
| - | === Core | + | === Core & Panel Domains === |
=== Sodium Binding Sites === | === Sodium Binding Sites === | ||
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=== Significant Residues === | === Significant Residues === | ||
| - | == | + | == Molecular Mechanism == |
| - | === Bile Salt Uptake === | + | === Mechanism of Bile Salt Uptake === |
| - | === HBV/HDV Infection === | + | === Mechanism of HBV/HDV Infection === |
== Medical Relevance == | == Medical Relevance == | ||
| - | == | + | == Relevance == |
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
| - | == References == | + | === References === |
<references/> | <references/> | ||
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| + | === Student Contributors === | ||
Revision as of 18:06, 13 March 2023
Sodium-taurocholate Co-transporting Polypeptide
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References
