Introduction

NTCP is found within the membrane of liver cells, and its primary role is to facilitate the transport of bile salts into hepatocytes from the bloodstream. This is important because 90% of human bile salts are recycled daily, no the function of NTCP is critical in providing bile salts to solubilize fats for digestion. There are two characteristic domains of NTCP, including the core domain and panel domain. There are also two different conformational states that have been identified that have implications for how the transport of bile salts occurs, although the exact molecular mechanism is not yet known. In addition to transporting bile salts into the cytoplasm of hepatocytes, NTCP also serves as a receptor for HBV and HDV virus.

Function

Bile Salt Uptake

HBV/HDV Infection

Structure

Proline/Glycine Hinge

Core & Panel Domains

Sodium Binding Sites

Significant Residues

Molecular Mechanism

Mechanism of Bile Salt Uptake

Mechanism of HBV/HDV Infection

Medical Relevance

Relevance

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