Sandbox Reserved 1769
From Proteopedia
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== Introduction == | == Introduction == | ||
- | NTCP is found within the membrane of | + | NTCP is found within the membrane of [https://en.wikipedia.org/wiki/Hepatocyte hepatocyte], and its primary role is to facilitate the transport of bile salts into hepatocytes from the bloodstream. This is important because 90% of human bile salts are recycled daily, no the function of NTCP is critical in providing bile salts to solubilize fats for digestion. There are two characteristic domains of NTCP, including the core domain and panel domain. There are also two different conformational states that have been identified that have implications for how the transport of bile salts occurs, although the exact molecular mechanism is not yet known. In addition to transporting bile salts into the cytoplasm of hepatocytes, NTCP also serves as a receptor for HBV and HDV virus. |
== Function == | == Function == |
Revision as of 17:57, 13 March 2023
Sodium-taurocholate Co-transporting Polypeptide
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References