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8chu
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human PURA repeat I-II K97E mutant== | |
| - | + | <StructureSection load='8chu' size='340' side='right'caption='[[8chu]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8chu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CHU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: Janowski | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8chu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8chu OCA], [https://pdbe.org/8chu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8chu RCSB], [https://www.ebi.ac.uk/pdbsum/8chu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8chu ProSAT]</span></td></tr> |
| - | [[Category: Niessing | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PURA_HUMAN PURA_HUMAN] Severe neonatal hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion;PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PURA_HUMAN PURA_HUMAN] This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Janowski R]] | ||
| + | [[Category: Niessing D]] | ||
Current revision
Crystal structure of human PURA repeat I-II K97E mutant
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