8gcp

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'''Unreleased structure'''
 
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The entry 8gcp is ON HOLD
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==Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein==
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<StructureSection load='8gcp' size='340' side='right'caption='[[8gcp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Huang, S., Mengyao, X., Lei, L., Jiangqian, M., Sheng, C., Sun, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gcp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GCP FirstGlance]. <br>
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Description: Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P2E:(Z)-7-[(1R,2R,3R)-3-HYDROXY-2-[(E,3S)-3-HYDROXYOCT-1-ENYL]-5-OXO-CYCLOPENTYL]HEPT-5-ENOIC+ACID'>P2E</scene></td></tr>
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[[Category: Huang, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gcp OCA], [https://pdbe.org/8gcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gcp RCSB], [https://www.ebi.ac.uk/pdbsum/8gcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gcp ProSAT]</span></td></tr>
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[[Category: Mengyao, X]]
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</table>
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[[Category: Lei, L]]
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== Function ==
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[[Category: Sheng, C]]
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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[[Category: Sun, J]]
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== References ==
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[[Category: Jiangqian, M]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang SM]]
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[[Category: Liu L]]
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[[Category: Mu J]]
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[[Category: Sheng C]]
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[[Category: Sun J]]
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[[Category: Xiong MY]]

Revision as of 11:01, 3 January 2024

Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein

PDB ID 8gcp

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