1k6y

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{{STRUCTURE_1k6y| PDB=1k6y | SCENE= }}
{{STRUCTURE_1k6y| PDB=1k6y | SCENE= }}
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'''Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase'''
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===Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase===
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==Overview==
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Retroviral integrase, an essential enzyme for replication of human immunodeficiency virus type-1 (HIV-1) and other retroviruses, contains three structurally distinct domains, an N-terminal domain, the catalytic core and a C-terminal domain. To elucidate their spatial arrangement, we have solved the structure of a fragment of HIV-1 integrase comprising the N-terminal and catalytic core domains. This structure reveals a dimer interface between the N-terminal domains different from that observed for the isolated domain. It also complements the previously determined structure of the C-terminal two domains of HIV-1 integrase; superposition of the conserved catalytic core of the two structures results in a plausible full-length integrase dimer. Furthermore, an integrase tetramer formed by crystal lattice contacts bears structural resemblance to a related bacterial transposase, Tn5, and exhibits positively charged channels suitable for DNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 11743009 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11743009}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: Integrase]]
[[Category: Integrase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:22:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:52:44 2008''

Revision as of 06:52, 2 July 2008

Image:1k6y.png

Template:STRUCTURE 1k6y

Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase

Template:ABSTRACT PUBMED 11743009

About this Structure

1K6Y is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein., Wang JY, Ling H, Yang W, Craigie R, EMBO J. 2001 Dec 17;20(24):7333-43. PMID:11743009

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