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1k85

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[[Image:1k85.jpg|left|200px]]
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{{STRUCTURE_1k85| PDB=1k85 | SCENE= }}
{{STRUCTURE_1k85| PDB=1k85 | SCENE= }}
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'''Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.'''
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===Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.===
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==Overview==
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Growing evidence suggests that horizontal gene transfer plays an integral role in the evolution of bacterial genomes. One of the debated examples of horizontal gene transfer from animal to prokaryote is the fibronectin type III domain (FnIIID). Certain extracellular proteins of soil bacteria contain an unusual cluster of FnIIIDs, which show sequence similarity to those of animals and are likely to have been acquired horizontally from animals. Here we report the solution structure of the FnIIID of chitinase A1 from Bacillus circulans WL-12. To the best of our knowledge, this is the first tertiary structure to be reported for an FnIIID from a bacterial protein. The structure of the domain shows significant similarity to FnIIIDs from animal proteins. Sequence comparisons with FnIIIDs from other soil bacteria proteins show that the core-forming residues are highly conserved and, thus, are under strong evolutionary pressure. Striking similarities in the tertiary structures of bacterial FnIIIDs and their mammalian counterparts may support the hypothesis that the evolution of the FnIIID in bacterial carbohydrases occurred horizontally. The total lack of surface-exposed aromatic residues also suggests that the role of this FnIIID is different from those of other bacterial beta-sandwich domains, which function as carbohydrate-binding modules.
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The line below this paragraph, {{ABSTRACT_PUBMED_11600504}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11600504 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11600504}}
==About this Structure==
==About this Structure==
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1K85 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K85 OCA].
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1K85 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K85 OCA].
==Reference==
==Reference==
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[[Category: Fibronectin type iii domain]]
[[Category: Fibronectin type iii domain]]
[[Category: Horizontal gene transfer]]
[[Category: Horizontal gene transfer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:25:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:55:36 2008''

Revision as of 06:55, 2 July 2008

Image:1k85.png

Template:STRUCTURE 1k85

Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.

Template:ABSTRACT PUBMED 11600504

About this Structure

1K85 is a Single protein structure of sequence from Bacillus circulans. Full experimental information is available from OCA.

Reference

Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1., Jee JG, Ikegami T, Hashimoto M, Kawabata T, Ikeguchi M, Watanabe T, Shirakawa M, J Biol Chem. 2002 Jan 11;277(2):1388-97. Epub 2001 Oct 12. PMID:11600504

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