Introduction

Structure

Antigen Binding Site

The binding of an antigen to the human B Cell receptor is identical to other common soluble antibodies (such as IgG). The antibody portion of the B Cell Receptor is roughly "Y" shaped that consists of two identical heavy and two identical light chains creating two similar epitope or binding regions. Thus, two antigen molecules can bind independent of one another to produce the same response. Within this structure, there are both constant and variable regions. The stem of the "Y" is a constant region composed of only hevay chain interactions. (Fc). The two heavy chains then branch at a felxible hinge region. These interact indivisdually with onelight chain creating the two tips of the "Y" termed Fab fragments. Each Fab fragment contains a variable region (Fv). and a constant region. Furthermore, the light chains interact with the heavy chains via weak intermolecular forces and disulfide bridges.

Heavy Chain Interactions (Iga and IgB)

Transmembrane Interactions

Function

Proposed Conformational Changes

Signal Pathway