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Introduction

Biological Introduction

SHOC2-PP1C-MRAS is a human enzyme that is involved in regulating cell proliferation and division^[1]. The enzyme is involved in the vast RAS-MAPK pathway, which is initially activated by an extracellular growth factor binding to a membrane bound RAS GTPase[1] such as HRAS, NRAS, or KRAS. RAS-GTPases are a family of proteins that work by functioning as molecular switches. This occurs from the protein alternating between binding GTP to be active and GDP to be inactive ^[2]. After activation via an extracellular growth factor, the RAS-GTPase enzyme binds GTP, which activates RAF^[3].

Structural Introduction

The active holoenzyme contains 3 domains. The SHOC-2(blue), PP1C(coral), and MRAS (green) domains form the complete

SHOC-2 is a scaffolding protein that holds the other subunits in the correct orientation, allowing for the holoenzyme to be functional.

Biological Function

Relevance

test reference^[4]

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.