8g5a

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Current revision (08:54, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8g5a is ON HOLD until 2025-02-12
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==X-31 hemagglutinin in complex with FL-1061 Fab==
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<StructureSection load='8g5a' size='340' side='right'caption='[[8g5a]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8g5a]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G5A FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g5a OCA], [https://pdbe.org/8g5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g5a RCSB], [https://www.ebi.ac.uk/pdbsum/8g5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g5a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A4JZ28_9INFA A4JZ28_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
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__TOC__
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</StructureSection>
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[[Category: Influenza A virus]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Schmidt AG]]
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[[Category: Thornlow D]]
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[[Category: Windsor IW]]

Current revision

X-31 hemagglutinin in complex with FL-1061 Fab

PDB ID 8g5a

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