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1k95

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{{STRUCTURE_1k95| PDB=1k95 | SCENE= }}
{{STRUCTURE_1k95| PDB=1k95 | SCENE= }}
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'''Crystal structure of des(1-52)grancalcin with bound calcium'''
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===Crystal structure of des(1-52)grancalcin with bound calcium===
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==Overview==
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Grancalcin is a cytosolic Ca(2+)-binding protein originally identified in human neutrophils. It belongs to a new class of EF-hand proteins, called PEF proteins, which contain five EF-hand motifs. At the N-terminus of grancalcin there is a approximately 50 residue-long segment rich in glycines and prolines. The fifth EF-hand, unpaired within the monomer, provides a means for dimerization through pairing with its counterpart in a second molecule. The structure of full-length grancalcin in the apo form and with one EF3 within the dimer occupied by a Ca(2+) ion have been determined. Although the N-terminal segment was present in the molecule, this part was disordered in the crystals. Here, the structure of a truncated form of grancalcin, which is lacking 52 N-terminal residues, in the presence and absence of Ca(2+) is presented. In the Ca(2+)-bound form the ions are found in the EF1 and EF3 hands. Binding of Ca(2+) to these two EF hands produces only minor conformational changes, mostly within the EF1 Ca(2+)-binding loop. This observation supports the hypothesis, formulated on the basis of the structure of a homologous protein ALG-2 which shows significant differences in the orientation of EF4 and EF5 compared with grancalcin, that calcium is a necessary factor but not sufficient alone for inducing a significant conformational change in PEF proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 11717497 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11717497}}
==About this Structure==
==About this Structure==
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[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
[[Category: Penta-ef-hand protein]]
[[Category: Penta-ef-hand protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:27:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:58:36 2008''

Revision as of 06:58, 2 July 2008

Image:1k95.png

Template:STRUCTURE 1k95

Crystal structure of des(1-52)grancalcin with bound calcium

Template:ABSTRACT PUBMED 11717497

About this Structure

1K95 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of Ca(2+)-loaded human grancalcin., Jia J, Borregaard N, Lollike K, Cygler M, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1843-9. Epub 2001, Nov 21. PMID:11717497

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