1k9a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k9a.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k9a.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k9a| PDB=1k9a | SCENE= }}
{{STRUCTURE_1k9a| PDB=1k9a | SCENE= }}
-
'''Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution'''
+
===Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution===
-
==Overview==
+
<!--
-
The carboxyl-terminal Src kinase (Csk) is an indispensable negative regulator for the Src family tyrosine kinases (SFKs) that play pivotal roles in various cell signalings. To understand the molecular basis of the Csk-mediated regulation of SFKs, we elucidated the crystal structure of full-length Csk. The Csk crystal consists of six molecules classified as active or inactive states according to the coordinations of catalytic residues. Csk assembles the SH2 and SH3 domains differently from inactive SFKs, and their binding pockets are oriented outward enabling the intermolecular interaction. In active molecules, the SH2-kinase and SH2-SH3 linkers are tightly stuck to the N-lobe of the kinase domain to stabilize the active conformation, and there is a direct linkage between the SH2 and the kinase domains. In inactive molecules, the SH2 domains are rotated destroying the linkage to the kinase domain. Cross-correlation matrices for the active molecules reveal that the SH2 domain and the N-lobe of the kinase domain move as a unit. These observations suggest that Csk can be regulated through coupling of the SH2 and kinase domains and that Csk provides a novel built-in activation mechanism for cytoplasmic tyrosine kinases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11884384}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11884384 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11884384}}
==About this Structure==
==About this Structure==
Line 47: Line 51:
[[Category: Src homology]]
[[Category: Src homology]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:27:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:59:04 2008''

Revision as of 06:59, 2 July 2008

Image:1k9a.png

Template:STRUCTURE 1k9a

Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution

Template:ABSTRACT PUBMED 11884384

About this Structure

1K9A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the carboxyl-terminal Src kinase, Csk., Ogawa A, Takayama Y, Sakai H, Chong KT, Takeuchi S, Nakagawa A, Nada S, Okada M, Tsukihara T, J Biol Chem. 2002 Apr 26;277(17):14351-4. Epub 2002 Mar 7. PMID:11884384

Page seeded by OCA on Wed Jul 2 09:59:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k9a"
Personal tools