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1k9m

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[[Image:1k9m.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1k9m| PDB=1k9m | SCENE= }}
{{STRUCTURE_1k9m| PDB=1k9m | SCENE= }}
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'''Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui'''
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===Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui===
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==Overview==
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Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center. Their location suggests that they inhibit protein synthesis by blocking the egress of nascent polypeptides. The saccharide branch attached to C5 of the lactone rings extends toward the peptidyl transferase center, and the isobutyrate extension of the carbomycin A disaccharide overlaps the A-site. Unexpectedly, a reversible covalent bond forms between the ethylaldehyde substituent at the C6 position of the 16-membered macrolides and the N6 of A2103 (A2062, E. coli). Mutations in 23S rRNA that result in clinical resistance render the binding site less complementary to macrolides.
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(as it appears on PubMed at http://www.pubmed.gov), where 12150912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12150912}}
==About this Structure==
==About this Structure==
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[[Category: Antibiotic]]
[[Category: Antibiotic]]
[[Category: Tylosin]]
[[Category: Tylosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:28:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:59:57 2008''

Revision as of 07:00, 2 July 2008

Image:1k9m.png

Template:STRUCTURE 1k9m

Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui

Template:ABSTRACT PUBMED 12150912

About this Structure

1K9M is a Protein complex structure of sequences from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

The structures of four macrolide antibiotics bound to the large ribosomal subunit., Hansen JL, Ippolito JA, Ban N, Nissen P, Moore PB, Steitz TA, Mol Cell. 2002 Jul;10(1):117-28. PMID:12150912

Page seeded by OCA on Wed Jul 2 09:59:57 2008

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