1ka4

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{{STRUCTURE_1ka4| PDB=1ka4 | SCENE= }}
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'''Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb'''
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===Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb===
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==Overview==
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The structure of Pyrococcus furiosus carboxypeptidase (PfuCP) has been determined to 2.2 A resolution using multiwavelength anomalous diffraction (MAD) methods. PfuCP represents the first structure of the new M32 family of carboxypeptidases. The overall structure is comprised of a homodimer. Each subunit is mostly helical with its most pronounced feature being a deep substrate binding groove. The active site lies at the bottom of this groove and contains an HEXXH motif that coordinates the metal ion required for catalysis. Surprisingly, the structure is similar to the recently reported rat neurolysin. Comparison of these structures as well as sequence analyses with other homologous proteins reveal several conserved residues. The roles for these conserved residues in the catalytic mechanism are inferred based on modeling and their location.
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(as it appears on PubMed at http://www.pubmed.gov), where 11839307 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11839307}}
==About this Structure==
==About this Structure==
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[[Category: M32 family]]
[[Category: M32 family]]
[[Category: Metallopeptidase]]
[[Category: Metallopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:29:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:01:07 2008''

Revision as of 07:01, 2 July 2008

Image:1ka4.png

Template:STRUCTURE 1ka4

Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb

Template:ABSTRACT PUBMED 11839307

About this Structure

1KA4 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus., Arndt JW, Hao B, Ramakrishnan V, Cheng T, Chan SI, Chan MK, Structure. 2002 Feb;10(2):215-24. PMID:11839307

Page seeded by OCA on Wed Jul 2 10:01:07 2008

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