8ge0

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'''Unreleased structure'''
 
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The entry 8ge0 is ON HOLD until Paper Publication
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==Crystal structure of JADE1 PZP domain in complex with Histone H3==
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<StructureSection load='8ge0' size='340' side='right'caption='[[8ge0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ge0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GE0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ge0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ge0 OCA], [https://pdbe.org/8ge0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ge0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ge0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ge0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN] [https://www.uniprot.org/uniprot/JADE1_HUMAN JADE1_HUMAN] Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).<ref>PMID:15502158</ref> <ref>PMID:16046545</ref> <ref>PMID:16387653</ref> <ref>PMID:19187766</ref> <ref>PMID:20129055</ref> <ref>PMID:22654112</ref> <ref>PMID:24065767</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Klein BJ]]
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[[Category: Kutateladze TG]]
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[[Category: Liu J]]

Revision as of 13:14, 13 March 2024

Crystal structure of JADE1 PZP domain in complex with Histone H3

PDB ID 8ge0

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OCA

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