1kb9

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{{Seed}}
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{{STRUCTURE_1kb9| PDB=1kb9 | SCENE= }}
{{STRUCTURE_1kb9| PDB=1kb9 | SCENE= }}
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'''YEAST CYTOCHROME BC1 COMPLEX'''
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===YEAST CYTOCHROME BC1 COMPLEX===
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==Overview==
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Biochemical data have shown that specific, tightly bound phospholipids are essential for activity of the cytochrome bc1 complex (QCR), an integral membrane protein of the respiratory chain. However, the structure and function of such phospholipids are not yet known. Here we describe five phospholipid molecules and one detergent molecule in the X-ray structure of yeast QCR at 2.3 A resolution. Their individual binding sites suggest specific roles in facilitating structural and functional integrity of the enzyme. Interestingly, a phosphatidylinositol molecule is bound in an unusual interhelical position near the flexible linker region of the Rieske iron-sulfur protein. Two possible proton uptake pathways at the ubiquinone reduction site have been identified: the E/R and the CL/K pathway. Remarkably, cardiolipin is positioned at the entrance to the latter. We propose that cardiolipin ensures structural integrity of the proton-conducting protein environment and takes part directly in proton uptake. Site-directed mutagenesis of ligating residues confirmed the importance of the phosphatidylinositol- and cardiolipin-binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 11726495 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11726495}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquinone]]
[[Category: Ubiquinone]]
[[Category: Undecyl-maltopyranoside]]
[[Category: Undecyl-maltopyranoside]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:31:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:04:33 2008''

Revision as of 07:04, 2 July 2008

Image:1kb9.png

Template:STRUCTURE 1kb9

YEAST CYTOCHROME BC1 COMPLEX

Template:ABSTRACT PUBMED 11726495

About this Structure

1KB9 is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure., Lange C, Nett JH, Trumpower BL, Hunte C, EMBO J. 2001 Dec 3;20(23):6591-600. PMID:11726495

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