1kbg

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[[Image:1kbg.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1kbg| PDB=1kbg | SCENE= }}
{{STRUCTURE_1kbg| PDB=1kbg | SCENE= }}
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'''MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2'''
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===MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2===
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==Overview==
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T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/delta TCR, specific for the disaccharide, even on glycolipids. The crystal structure of Kb/RGY8-6H-Gal2 now demonstrates that the peptide and H-2Kb structures are unaffected by the peptide glycosylation, but the central region of the putative TCR binding site is dominated by the extensive exposure of the tethered carbohydrate. These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response.
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The line below this paragraph, {{ABSTRACT_PUBMED_10023770}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10023770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10023770}}
==About this Structure==
==About this Structure==
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[[Category: Synthetic peptide]]
[[Category: Synthetic peptide]]
[[Category: Vaccine]]
[[Category: Vaccine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:32:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:05:02 2008''

Revision as of 07:05, 2 July 2008

Image:1kbg.png

Template:STRUCTURE 1kbg

MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2

Template:ABSTRACT PUBMED 10023770

About this Structure

1KBG is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL., Speir JA, Abdel-Motal UM, Jondal M, Wilson IA, Immunity. 1999 Jan;10(1):51-61. PMID:10023770

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