4uw5

Publication Abstract from PubMed

Galectins are evolutionarily conserved and ubiquitously present animal lectins with a high affinity for beta-galactose containing oligosaccharides. To date, 15 mammalian galectins have been identified. Their involvement in cell-cell and cell-matrix interactions has highlighted their importance in signal transduction and other intracellular processes. Human Galectin-7 (hGal-7) is a 15kDa prototype galectin forms a dimer in solution and its involvement in the stimulation and development of tumour growth has been reported. Previously we had reported the crystal structure of hGal-7 and its complex with galactose and lactose which have provided insight into its molecular recognition and detailed interactions. Here, we present the newly obtained high resolution structural data on carbohydrate based dendrons in complex with hGal-7. Our crystallographic data reveal how multivalent ligands interact with and form cross-links with these galectin molecules. Understanding how these dendrimeric compounds interact with hGal-7 would help the design of new tools to investigate the recognition of carbohydrates by lectins. This article is protected by copyright. All rights reserved.

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.,Ramaswamy S, Haj Sleiman M, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR FEBS J. 2014 Nov 4. doi: 10.1111/febs.13140. PMID:25367374^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.