This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4w5c
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4w5c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W5C FirstGlance]. <br> | <table><tr><td colspan='2'>[[4w5c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W5C FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H5:N-(1H-BENZIMIDAZOL-2-YL)-1,3-DIMETHYL-1H-PYRAZOLE-4-CARBOXAMIDE'>3H5</scene>, <scene name='pdbligand=3H6:N-(1H-BENZIMIDAZOL-2-YL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE'>3H6</scene>, <scene name='pdbligand=3H7:4,6-DIFLUORO-1,3-BENZOTHIAZOL-2-AMINE'>3H7</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.27Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3H5:N-(1H-BENZIMIDAZOL-2-YL)-1,3-DIMETHYL-1H-PYRAZOLE-4-CARBOXAMIDE'>3H5</scene>, <scene name='pdbligand=3H6:N-(1H-BENZIMIDAZOL-2-YL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE'>3H6</scene>, <scene name='pdbligand=3H7:4,6-DIFLUORO-1,3-BENZOTHIAZOL-2-AMINE'>3H7</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5c OCA], [https://pdbe.org/4w5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w5c RCSB], [https://www.ebi.ac.uk/pdbsum/4w5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w5c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5c OCA], [https://pdbe.org/4w5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w5c RCSB], [https://www.ebi.ac.uk/pdbsum/4w5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w5c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Current revision
Crystal structure analysis of cruzain with three Fragments: 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino-4,6-difluorobenzothiazole) and 9 (N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide).
| |||||||||||
