Introduction
Receptor Tyrosine Kinase Receptor
Figure 1: Mechanism for Shoc2-MRAS-PP1C
Figure 2: PP1C phosphorylates Serine 259.
Overall Structure
SHOC2
PP1C
MRAS
Key Ligand Interactions
Figure 3: Electrostatic illustration of the amphipathic binding pocket of the LPA
1 receptor. This binding pocket was revealed by cutting away the exterior or the protein. This binding pocket, located in the interior of the protein, has both polar and nonpolar regions. The blue and red coloration highlight the positively and negatively charged regions, respectively, and the white color shows the nonpolar region of the binding pocket.
SHOC2 and PP1C
SHOC2 and MRAS
PP1C and MRAS
Signaling Pathway
Disease Relevance
Cancer
RASopathies
Future Studies
3D structures of lysophosphatidic acid receptor
4z34, 4z35, 4z36 - hLPA1 + antagonist - human
2lq4 – hLPA1 second extracellular loop – NMR
4p0c – hLPA2/NHERF2
5xsz – LPA6A (mutant) – zebra fish
References
Proteopedia Resources
Category:Lysophosphatidic acid binding
Category:Lysophosphatidic acid
Butler University Proteopedia Pages
See also:
