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1kek

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{{STRUCTURE_1kek| PDB=1kek | SCENE= }}
{{STRUCTURE_1kek| PDB=1kek | SCENE= }}
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'''Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase'''
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===Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase===
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==Overview==
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In anaerobic organisms, the decarboxylation of pyruvate, a crucial component of intermediary metabolism, is catalyzed by the metalloenzyme pyruvate: ferredoxin oxidoreductase (PFOR) resulting in the generation of low potential electrons and the subsequent acetylation of coenzyme A (CoA). PFOR is the only enzyme for which a stable acetyl thiamine diphosphate (ThDP)-based free radical reaction intermediate has been identified. The 1.87 A-resolution structure of the radical form of PFOR from Desulfovibrio africanus shows that, despite currently accepted ideas, the thiazole ring of the ThDP cofactor is markedly bent, indicating a drastic reduction of its aromaticity. In addition, the bond connecting the acetyl group to ThDP is unusually long, probably of the one-electron type already described for several cation radicals but not yet found in a biological system. Taken together, our data, along with evidence from the literature, suggest that acetyl-CoA synthesis by PFOR proceeds via a condensation mechanism involving acetyl (PFOR-based) and thiyl (CoA-based) radicals.
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(as it appears on PubMed at http://www.pubmed.gov), where 11752578 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11752578}}
==About this Structure==
==About this Structure==
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[[Category: 7 domain]]
[[Category: 7 domain]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:38:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:13:21 2008''

Revision as of 07:13, 2 July 2008

Image:1kek.png

Template:STRUCTURE 1kek

Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase

Template:ABSTRACT PUBMED 11752578

About this Structure

1KEK is a Single protein structure of sequence from Desulfovibrio africanus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase., Chabriere E, Vernede X, Guigliarelli B, Charon MH, Hatchikian EC, Fontecilla-Camps JC, Science. 2001 Dec 21;294(5551):2559-63. PMID:11752578

Page seeded by OCA on Wed Jul 2 10:13:21 2008

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