8ckl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8ckl is ON HOLD until Paper Publication
+
==Semaphorin-5A TSR 3-4 domains in complex with sucrose octasulfate (SOS)==
-
 
+
<StructureSection load='8ckl' size='340' side='right'caption='[[8ckl]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8ckl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CKL FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GU4:2,3,4,6-TETRA-O-SULFONATO-ALPHA-D-GLUCOPYRANOSE'>GU4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900013:sucrose+octasulfate'>PRD_900013</scene>, <scene name='pdbligand=YYJ:1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose'>YYJ</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ckl OCA], [https://pdbe.org/8ckl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ckl RCSB], [https://www.ebi.ac.uk/pdbsum/8ckl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ckl ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Monosomy 5p.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SEM5A_HUMAN SEM5A_HUMAN] Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.<ref>PMID:15218527</ref> <ref>PMID:19850054</ref> <ref>PMID:20696765</ref> <ref>PMID:21706053</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Duman R]]
 +
[[Category: El Omari K]]
 +
[[Category: Harlos K]]
 +
[[Category: Jones EY]]
 +
[[Category: Nagy GN]]
 +
[[Category: Wagner A]]

Revision as of 09:34, 1 March 2024

Semaphorin-5A TSR 3-4 domains in complex with sucrose octasulfate (SOS)

PDB ID 8ckl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8ckl"
Personal tools