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1key

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{{STRUCTURE_1key| PDB=1key | SCENE= }}
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'''Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)'''
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===Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)===
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==Overview==
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The testis/brain-RNA-binding protein (TB-RBP) spatially and temporally controls the expression of specific mRNAs in developing male germ cells and brain cells, and is implicated in DNA recombination and repair events. We report the 2.65 A crystal structure of mouse TB-RBP. The structure is predominantly alpha-helical and exhibits a novel protein fold and mode of assembly. Crystal symmetry and molecular symmetry combine to form an octet of TB-RBP monomers in the shape of an elongated spherical particle with a large cavity at its center. Amino acid residues that affect RNA and DNA binding are located on the interior surface of the assembled particle, and a putative nucleotide-binding domain that controls RNA binding is located at a dimer interface. Other modes of assembly are suggested for TB-RBP based on our structure and recently reported electron microscopic reconstructions of human TB-RBP.
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(as it appears on PubMed at http://www.pubmed.gov), where 12079346 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12079346}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
[[Category: Tetramer/octamer assembly]]
[[Category: Tetramer/octamer assembly]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:39:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:14:31 2008''

Revision as of 07:14, 2 July 2008

Image:1key.png

Template:STRUCTURE 1key

Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)

Template:ABSTRACT PUBMED 12079346

About this Structure

1KEY is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein., Pascal JM, Hart PJ, Hecht NB, Robertus JD, J Mol Biol. 2002 Jun 21;319(5):1049-57. PMID:12079346

Page seeded by OCA on Wed Jul 2 10:14:31 2008

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