1kgy

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{{STRUCTURE_1kgy| PDB=1kgy | SCENE= }}
{{STRUCTURE_1kgy| PDB=1kgy | SCENE= }}
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'''Crystal Structure of the EphB2-ephrinB2 complex'''
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===Crystal Structure of the EphB2-ephrinB2 complex===
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==Overview==
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The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are important in regulating cell-cell interactions as they initiate a unique bidirectional signal transduction cascade whereby information is communicated into both the Eph-expressing and the ephrin-expressing cells. Initially identified as regulators of axon pathfinding and neuronal cell migration, Ephs and ephrins are now known to have roles in many other cell-cell interactions, including those of vascular endothelial cells and specialized epithelia. Here we report the crystal structure of the complex formed between EphB2 and ephrin-B2, determined at 2.7 A resolution. Each Eph receptor binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an extended ephrin loop into a channel at the surface of the receptor. Two Eph-Ephrin dimers then join to form a tetramer, in which each ligand interacts with two receptors and each receptor interacts with two ligands. The Eph and ephrin molecules are precisely positioned and orientated in these complexes, promoting higher-order clustering and the initiation of bidirectional signalling.
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The line below this paragraph, {{ABSTRACT_PUBMED_11780069}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11780069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11780069}}
==About this Structure==
==About this Structure==
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[[Category: Rajashankar, K R.]]
[[Category: Rajashankar, K R.]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:44:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:19:41 2008''

Revision as of 07:19, 2 July 2008

Image:1kgy.png

Template:STRUCTURE 1kgy

Crystal Structure of the EphB2-ephrinB2 complex

Template:ABSTRACT PUBMED 11780069

About this Structure

1KGY is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an Eph receptor-ephrin complex., Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB, Nature. 2001 Dec 20-27;414(6866):933-8. PMID:11780069

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