1kh2

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{{STRUCTURE_1kh2| PDB=1kh2 | SCENE= }}
{{STRUCTURE_1kh2| PDB=1kh2 | SCENE= }}
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'''Crystal Structure of Thermus thermophilus HB8 Argininosuccinate Synthetase in complex with ATP'''
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===Crystal Structure of Thermus thermophilus HB8 Argininosuccinate Synthetase in complex with ATP===
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==Overview==
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Argininosuccinate synthetase catalyzes the ATP-dependent condensation of a citrulline with an aspartate to give argininosuccinate. The three-dimensional structures of the enzyme from Thermus thermophilus HB8 in its free form, complexed with intact ATP, and complexed with an ATP analogue (adenylyl imidodiphosphate) and substrate analogues (arginine and succinate) have been determined at 2.3-, 2.3-, and 1.95-A resolution, respectively. The structure is essentially the same as that of the Escherichia coli argininosuccinate synthetase. The small domain has the same fold as that of a new family of "N-type" ATP pyrophosphatases with the P-loop specific for the pyrophosphate of ATP. However, the enzyme shows the P-loop specific for the gamma-phosphate of ATP. The structure of the complex form is quite similar to that of the native one, indicating that no conformational change occurs upon the binding of ATP and the substrate analogues. ATP and the substrate analogues are bound to the active site with their reaction sites close to one another and located in a geometrical orientation favorable to the catalytic action. The reaction mechanism so far proposed seems to be consistent with the locations of ATP and the substrate analogues. The reaction may proceed without the large conformational change of the enzyme proposed for the catalytic process.
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(as it appears on PubMed at http://www.pubmed.gov), where 11844799 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11844799}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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Revision as of 07:20, 2 July 2008

Image:1kh2.png

Template:STRUCTURE 1kh2

Crystal Structure of Thermus thermophilus HB8 Argininosuccinate Synthetase in complex with ATP

Template:ABSTRACT PUBMED 11844799

About this Structure

1KH2 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of argininosuccinate synthetase from Thermus thermophilus HB8. Structural basis for the catalytic action., Goto M, Nakajima Y, Hirotsu K, J Biol Chem. 2002 May 3;277(18):15890-6. Epub 2002 Feb 13. PMID:11844799

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