1kh6

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[[Image:1kh6.gif|left|200px]]
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{{STRUCTURE_1kh6| PDB=1kh6 | SCENE= }}
{{STRUCTURE_1kh6| PDB=1kh6 | SCENE= }}
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'''Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.'''
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===Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.===
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==Overview==
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The hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA drives internal initiation of viral protein synthesis during host cell infection. In the tertiary structure of the IRES RNA, two helical junctions create recognition sites for direct binding of the 40S ribosomal subunit and eukaryotic initiation factor 3 (eIF3). The 2.8 A resolution structure of the IIIabc four-way junction, which is critical for binding eIF3, reveals how junction nucleotides interact with an adjacent helix to position regions directly involved in eIF3 recognition. Two of the emergent helices stack to form a nearly continuous A-form duplex, while stacking of the other two helices is interrupted by the insertion of junction residues into the helix minor groove. This distorted stack probably serves as an important recognition surface for the translational machinery.
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The line below this paragraph, {{ABSTRACT_PUBMED_11927953}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11927953 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11927953}}
==About this Structure==
==About this Structure==
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[[Category: Rna structure]]
[[Category: Rna structure]]
[[Category: Translation]]
[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:44:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:20:24 2008''

Revision as of 07:20, 2 July 2008

Image:1kh6.png

Template:STRUCTURE 1kh6

Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.

Template:ABSTRACT PUBMED 11927953

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:11927953

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