1khp

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{{STRUCTURE_1khp| PDB=1khp | SCENE= }}
{{STRUCTURE_1khp| PDB=1khp | SCENE= }}
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'''Monoclinic form of papain/ZLFG-DAM covalent complex'''
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===Monoclinic form of papain/ZLFG-DAM covalent complex===
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==Overview==
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The three-dimensional structure of two polymorphs of a ZLFG-CH2-papain covalent complex has been determined by X-ray crystallography. The structures indicate that: (i) the methylene carbon atom of the inhibitor is covalently bound to the Sgamma atom of Cys25 of papain; (ii) the hydrophobic S2 pocket formed by Pro68, Val133, Val157, and Asp158 is occupied by the inhibitor's phenylalanyl P2 side chain; (iii) extensive hydrogen bonding and hydrophobic interactions are responsible for the interaction of the inhibitor with the enzyme. Comparison with similar structures suggests that in covalent complexes preservation of main chain-main chain interactions between the enzyme and the inhibitor may have higher priority than the P-S interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_15357669}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15357669 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15357669}}
==About this Structure==
==About this Structure==
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[[Category: Irreversible inhibitor]]
[[Category: Irreversible inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:45:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:21:48 2008''

Revision as of 07:21, 2 July 2008

Image:1khp.png

Template:STRUCTURE 1khp

Monoclinic form of papain/ZLFG-DAM covalent complex

Template:ABSTRACT PUBMED 15357669

About this Structure

1KHP is a Single protein structure of sequence from Carica papaya. Full crystallographic information is available from OCA.

Reference

Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor., Janowski R, Kozak M, Jankowska E, Grzonka Z, Jaskolski M, J Pept Res. 2004 Oct;64(4):141-50. PMID:15357669

Page seeded by OCA on Wed Jul 2 10:21:48 2008

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