1jnx
From Proteopedia
(New page: 200px<br /> <applet load="1jnx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jnx, resolution 2.5Å" /> '''Crystal structure of...) |
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| - | [[Image:1jnx.gif|left|200px]]<br /> | + | [[Image:1jnx.gif|left|200px]]<br /><applet load="1jnx" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1jnx" size=" | + | |
caption="1jnx, resolution 2.5Å" /> | caption="1jnx, resolution 2.5Å" /> | ||
'''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1'''<br /> | '''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we | + | The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NI as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Glover, J | + | [[Category: Glover, J N.M.]] |
[[Category: Green, R.]] | [[Category: Green, R.]] | ||
| - | [[Category: Williams, R | + | [[Category: Williams, R S.]] |
[[Category: NI]] | [[Category: NI]] | ||
[[Category: brct]] | [[Category: brct]] | ||
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[[Category: gene expression]] | [[Category: gene expression]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:42 2008'' |
Revision as of 11:24, 21 February 2008
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Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
Contents |
Overview
The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.
Disease
Known diseases associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]
About this Structure
1JNX is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086
Page seeded by OCA on Thu Feb 21 13:24:42 2008
Categories: Homo sapiens | Single protein | Glover, J N.M. | Green, R. | Williams, R S. | NI | Brct | Cancer | Gene expression
