1kil

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[[Image:1kil.gif|left|200px]]
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{{Seed}}
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[[Image:1kil.png|left|200px]]
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{{STRUCTURE_1kil| PDB=1kil | SCENE= }}
{{STRUCTURE_1kil| PDB=1kil | SCENE= }}
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'''Three-dimensional structure of the complexin/SNARE complex'''
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===Three-dimensional structure of the complexin/SNARE complex===
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==Overview==
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During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca(2+)-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca(2+)-evoked neurotransmitter release.
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The line below this paragraph, {{ABSTRACT_PUBMED_11832227}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11832227 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11832227}}
==About this Structure==
==About this Structure==
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[[Category: Tomchick, D.]]
[[Category: Tomchick, D.]]
[[Category: Helix bound to four helix bundle]]
[[Category: Helix bound to four helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:47:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:23:57 2008''

Revision as of 07:23, 2 July 2008

Image:1kil.png

Template:STRUCTURE 1kil

Three-dimensional structure of the complexin/SNARE complex

Template:ABSTRACT PUBMED 11832227

About this Structure

1KIL is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the complexin/SNARE complex., Chen X, Tomchick DR, Kovrigin E, Arac D, Machius M, Sudhof TC, Rizo J, Neuron. 2002 Jan 31;33(3):397-409. PMID:11832227

Page seeded by OCA on Wed Jul 2 10:23:57 2008

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