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1kix

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[[Image:1kix.gif|left|200px]]
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{{STRUCTURE_1kix| PDB=1kix | SCENE= }}
{{STRUCTURE_1kix| PDB=1kix | SCENE= }}
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'''Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA'''
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===Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA===
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==Overview==
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Telomeres are the specialized protein--DNA complexes that cap and protect the ends of linear eukaryotic chromosomes. The extreme 3' end of the telomeric DNA in Oxytricha nova is bound by a two-subunit sequence-specific and 3' end-specific protein called the telomere end-binding protein (OnTEBP). Here we describe the crystal structure of the alpha-subunit of OnTEBP in complex with T4G4 single-stranded telomeric DNA. This structure shows an (alpha--ssDNA)2 homodimer with a large approximately 7,000 A2 protein--protein interface in which the domains of alpha are rearranged extensively from their positions in the structure of an alpha--beta--ssDNA ternary complex. The (alpha--ssDNA)2 complex can bind two telomeres on opposite sides of the dimer and, thus, acts as a protein mediator of telomere--telomere associations. The structures of the (alpha--ssDNA)2 dimer presented here and the previously described alpha--beta--ssDNA complex demonstrate that OnTEBP forms multiple telomeric complexes that potentially mediate the assembly and disassembly of higher order telomeric structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_11836536}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11836536 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11836536}}
==About this Structure==
==About this Structure==
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[[Category: Ssdna]]
[[Category: Ssdna]]
[[Category: Telomere binding protein]]
[[Category: Telomere binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:48:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:24:43 2008''

Revision as of 07:24, 2 July 2008

Image:1kix.png

Template:STRUCTURE 1kix

Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA

Template:ABSTRACT PUBMED 11836536

About this Structure

1KIX is a Single protein structure of sequence from Sterkiella nova. Full crystallographic information is available from OCA.

Reference

Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA., Peersen OB, Ruggles JA, Schultz SC, Nat Struct Biol. 2002 Mar;9(3):182-7. PMID:11836536

Page seeded by OCA on Wed Jul 2 10:24:43 2008

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